Among them, IGF2R, GPC3, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP5, and IGFBP6, have the highest connectivity with others (≥ 20 interactions), and they were identified as the hub genes for CRC. The gene discussed is IGFBP5; the disease is colorectal carcinoma.