These findings have also been supported by animal studies, where PPARγ-null mice exhibited a higher sensitivity for insulin than wild-type mice, and what is more depletion of PPARγ protected against high-fat diet-induced insulin resistance However, still little is known regarding the modulation of the post-transcriptional activity of PPARγ that might modulate adipose tissue metabolic and hormonal function [8–10]. Here, PPARG is linked to Insulin resistance.