For peri-implantitis, the AUC for ET-1 was 0.72 (95% CI = 0.58–0.86, p < 0.01), with a cut-off value of 0.21, yielding a sensitivity of 92% and a specificity of 56% in the univariable analysis. The gene discussed is EDN1; the disease is Peri-Implantitis.