Gα11 has been found to carry dominant point mutations in autosomal dominant hypocalcemia and in hypocalciuric hypercalcemia, disorders of mineral homeostasis, including mutations in positions R181 and S211 (R177 and S207 mutated in GNAO1 encephalopathy) (48). This evidence concerns the gene GNA11 and familial hypocalciuric hypercalcemia.