The mutants were grouped following the OMIM catalog (https://omim.org/) that classifies GNAO1 encephalopathy into 2 disorders with distinct clinical manifestations: “developmental and epileptic encephalopathy-17” (DEE17; OMIM #615473) and “neurodevelopmental disorder with involuntary movements” (NEDIM; OMIM #617493) (Supplemental Table 1; supplemental material available online with this article; https://doi.org/10.1172/JCI172057DS1). Here, GNAO1 is linked to Encephalopathy.