The underlying molecular steps of dsDNA accumulation inducing ICAM1 expression were previously reported through NFkB, JNK and MAPK pathways.[22] To systemically evaluate the impact of DAC on the melanoma cell membrane expression of ICAM1 at protein level, A375 and SK‐MEL‐1 cells were pre‐treated with DAC (48h) and ICAM1 membrane expression were evaluated using flow cytometry. This evidence concerns the gene MAPK8 and melanoma.