Previous studied demonstrated that DNMT1 was a hallmark of melanoma and indicating poorer survival in melanoma patients.[14, 18] In TCGA of melanoma cohort, melanoma patients with high DNMT1 expression exhibited poorer disease‐free survival, but the difference was not statistically significant (Log‐rank p = 0.083; Supplement Figure S2E). The gene discussed is DNMT1; the disease is melanoma.