To further investigate the immunoregulatory roles of I1‐DXd and DAC combination on anti‐tumor immunity, we first established an immunocompetent animal model using murine melanoma B16OVA cells transduced with human ICAM1 genes (B16OVA‐hICAM1) (Supplement Figure S3A‐D), which is used to determine the in vivo efficacy of I1‐DXd and DAC combination. This evidence concerns the gene ICAM1 and melanoma.