The MR results using the IVW method showed two factors that were protective against prostate cancer: CUB domain-containing protein 1 (OR: 0.95, 95% CI: 0.91–0.99, P = 0.015) and Interleukin-10 receptor subunit beta (OR: 0.95, 95% CI: 0.91–0.98, P = 0.005). This evidence concerns the gene IL10RB and prostate cancer.