Hezaveh et al. 89 have demonstrated in a PDAC murine model, that macrophage AhR deletion (Lyz2cre/+Ahrfl/fl mice) results in proinflammatory polarization of TAMs, expression of PD-L1 in TAMS, and activated CD8+ T cell infiltration in the PDAC TME, ultimately resulting in reduced tumour burden compared to controls. The gene discussed is CD274; the disease is neoplasm.