TGFB1 and neoplasm: Cancer cells are thought to circumvent the tumor suppressive effects of TGFb via mutations or epigenetic modifications (Derynck et al., 2021; Kim et al., 2021; Massagué et al., 2000; Zhang et al., 2017; Seoane and Gomis, 2017; Suriyamurthy et al., 2019; Miyazawa and Miyazono, 2017; Tang et al., 2018).