Recruitment of monocytes by TGFb results in differentiation into macrophages that attach to the extracellular matrix (ECM) or promote blood vessel leakiness allowing for tumor cell extravasation (Arwert et al., 2018; Kelly et al., 2018; Kim et al., 2021; Allen et al., 1990; Wahl et al., 1993). Here, TGFB1 is linked to neoplasm.