The NaV1.2 channel, which is encoded by SCN2A, supports neuronal excitability and is expressed primarily in excitatory neurons.[27] Dysfunction of NaV1.2 channels has been identified as a leading cause of epilepsy in clinic.[10, 28] In IP‐MS results, NaV1.2 was specifically captured from the hippocampal lysate of PTPRN‐WT mice (Figure 4C; and Table S6, Supporting Information). Here, SCN2A is linked to epilepsy.