Research study using data from the cancer genome atlas (TCGA) identified that TERT, cell cycle regulator TP53, AXIN1, and RB1 genes, WNT pathway oncogene CTNNB1, and ARID1A, ARID2, and BAP1 which are chromatin remodeling players were significantly mutated in HCC [67]. This evidence concerns the gene TP53 and hepatocellular carcinoma.