[168] overexpressed DGAT2 in the liver of mice (Liv‐DGAT2) and found that Liv‐DGAT2 mice increased hepatic TG, DAG and ceramide spontaneously but their livers showed normal glucose and insulin tolerance and did not exhibit elevated inflammation, a prerequisite of MASH and HCC progression. Here, DGAT2 is linked to hepatocellular carcinoma.