TGFB1 and Hepatic fibrosis: During the initial stages of liver fibrosis, HSCs receive molecular signals from neighboring cells that can secrete various growth factors, thereby activating HSCs and promoting profibrotic factor secretion.[1b] Subsequently, the activated HSCs proliferate and secrete substantial quantities of ECM proteins, leading to ECM accumulation and fibrous scar formation.[18] To investigate the anti‐fibrotic effect of SecNPs, LX2 or HSC‐T6 cells were initially activated by the addition of a typical fibroblast growth factor, TGFβ1, followed by co‐incubation with SecNPs (Figure 2a).