NQO1 and hepatocellular carcinoma: HBV X protein (HBx) plays a crucial role in this process.[8] HBx, in acute liver failure, suppresses solute carrier family 7 member 11 expression through H3K27me3 modification by enhancer of zeste homolog 2.[8] In hepatoma cells, HBx directly recruits DNA methyltransferase 3A to the promoter region of the NAD(P)H:quinone oxidoreductase 1 (NQO1) gene to induce epigenetic silencing of NQO1.