Clearly illustrating this point is the identification of dominant negative mutations in TP53 that, worryingly, were the same dominant negative mutations most observed in human cancers.[14, 15, 48] Another gene associated with hematopoietic malignancies, BCOR, was also recently identified as recurrently mutated in hPSCs.[13] The full extent of recurrent SNVs is yet to be revealed as traditional cytogenetic techniques make way to newer sequencing‐based technologies, capable of nucleotide‐level resolution in the detection of genetic changes.[4]. The gene discussed is TP53; the disease is cancer.