NPPB and chronic kidney disease: Compared to those who maintained an eGFR ≥60 during the study period, a higher proportion of patients with NYHA class ≥III (75% vs. 40%, p = .04), higher levels of NT‐proBNP (3495 [1905–11 431] vs. 972 [542.2–2512], p = .001), higher serum Cr levels (1.1 ± 0.15 vs. 0.9 ± 0.14, p = .001), lower LVEF (45 ± 13 vs. 52 ± 8.3, p = .04), and higher rates of diuretic use (91.7% vs. 57.1%, p = .03) were noted among those who developed CKD (Table 2).