This modification promotes the CyPA‐CD147 interaction and in turn increases NSCLC cell‐derived CCL5 secretion by activating p38‐ZBTB32 signaling, which facilitates M2‐tumor‐associated macrophage infiltration in NSCLC tissues via the CCL5/CCR5 axis. This evidence concerns the gene CCL5 and non-small cell lung carcinoma.