Previous studies showed that the CCL5/CCR5 axis contributed to tumor progression by promoting the formation of an immunosuppressive TME, including M2‐TAM chemotaxis.[22, 23] Next, multi‐color immunofluorescence staining was performed using NSCLC tissues (Figure S9D, Supporting Information), and the results showed that the high CD147‐K148me2 group had more infiltrated CD68+CD206+ M2‐TAMs than did the low CD147‐K148me2 group (Figure S9E, Supporting Information). Here, CCR5 is linked to neoplasm.