A previous study identified a panel of lysine residues of CD147‐ECD modified by di‐methylation in NSCLC samples.[20] To screen for differential di‐methylation of CD147‐ECD between NSCLC and para‐carcinoma tissues, we collected 20 pairs of NSCLC and para‐carcinoma tissues and measured the abundance of CD147 di‐methylation at the residues of the CD147‐ECD using liquid chromatography‐tandem mass spectrometry (LC‐MS/MS). This evidence concerns the gene BSG and carcinoma.