Maintaining centromeric identity necessitates precise deposition of CENP‐A.[14, 15, 16] Aberrant overexpression of CENP‐A, which leads to its mislocalization, is associated with the malignant potential of tumors.[21, 22, 23, 24] Therefore, understanding the regulatory mechanisms of CENP‐A expression and degradation could shed light on cancer development. Here, CENPA is linked to cancer.