Overactivation of ASK1 has also been observed in DKD patients and animal models,29 and GS‐444217 was shown to halt the progression of glomerular sclerosis and improve renal function impairment associated with a reduction in kidney activation of p38, JNK and MAPK.30, 31, 32. This evidence concerns the gene MAPK8 and Glomerular sclerosis.