There is an increase in the ferroptosis‐related molecules TFR, HO‐1, and ferritin, and a decline in the ferroptosis regulatory proteins SLC7A11, GPX4, and FSP1 in the aorta of AD patients, suggesting the involvement of ferroptosis in VSMC dysfunction and AD development.104, 105. This evidence concerns the gene HMOX1 and Alzheimer disease.