Considering that molecular features with an unequivocal functional role in cancer cells such as p53 alterations,30 HER2 overexpression,31 and MYC32 have also failed to be prognostic in most studies on pT2–4 bladder cancer demonstrates that the absence of a prognostic relevance of the expression of a specific gene in urothelial cancer does rule out a relevant role in tumour biology. This evidence concerns the gene TP53 and cancer.