The model risk score was also used to assess doubt cases of PCa at biopsy and then compared to bi-parametric PI-RADS v2.<h4>Discussion</h4>This study explored the relative utility of a well-developed risk model by combining radiomics, Prostate-Specific Antigen levels and age for objective and accurate PCa risk stratification and supporting the process of making clinical decisions during follow up. This evidence concerns the gene KLK3 and posterior cortical atrophy.