<h4>Objective</h4>To explore the relationship between plasma lactoferrin (Lf) and glaucoma, assessing the clinical utility of Lf in glaucoma.<h4>Methods</h4>A cross-sectional study involved 161 glaucoma patients and 115 healthy controls, with a follow-up of 14 subjects after approximately 2 years. The gene discussed is LTF; the disease is glaucoma.