Lysyl oxidase (LOX) and LOX-like (LOXL) proteins (i.e., LOX family-LOX, LOXL1, LOXL2, LOXL3 and LOXL4) play crucial roles in ECM remodeling including crosslinking of collagens and elastin due and LOXL2 protein was identified as a secreted protein and localized in the extracellular matrix in active fibrotic diseases and in the early stromal reaction of breast cancer [2]. This evidence concerns the gene LOXL3 and breast cancer.