We identified a significant causal association between interleukin-2 (IL-2) and stem cell growth factor beta (SCGF-β) with hyperthyroidism (OR = 1.134, 95% CI: 1.037–1.241, p = 0.006; OR = 1.106, 95% CI: 1.019–1.202, p = 0.017, respectively). The gene discussed is IL2; the disease is hyperthyroidism.