This study aimed to verify the hypothesis that capsaicin attenuates salt-induced hypertension via the AMPK/Akt/Nrf2 pathway in hypothalamic paraventricular nucleus (PVN).<h4>Methods</h4>Dahl salt-sensitive (Dahl S) rats were used as animal model for the present study. This evidence concerns the gene AKT1 and hypertensive disorder.