Based on principal component analysis, increases in these 3 antibodies, without responses to DNB, GAC, and SpyCEP characterized <i>Streptococcus dysgalactiae subspecies equisimilis</i> (SDSE) infection.<h4>Conclusions</h4>SDSE appears to be the predominant cause of lower limb cellulitis. The gene discussed is GLS; the disease is infection.