No human LPGAT1 related disease has been described to date, but the phenotype of the mouse model partially recapitulates the human 3MGA, deafness, and encephalopathy, Leigh‐like (MEDGEL) syndrome caused by deficiency of SERAC1, another PG remodeller also localised to the MAM.24, 26. This evidence concerns the gene SERAC1 and Encephalopathy.