Although an elevated and prolonged induction Tgfb3 mRNA has been reported in experimental models of myocardial infarction (Dewald et al., 2004) and a polymorphism of TGF‐β3 is associated with changes in LV geometry in hypertensive patients (Hu et al., 2010), very little is known about its function in cardiac remodeling. Here, TGFB3 is linked to myocardial infarction.