A comparative analysis of PathGeNet in the CRC state showed a partial overlap of key genes as well as clustered genes such as MCM7, AURKA, FEN1, CDK1, POLD2, FCER1G, PT‐PRC, CCL2, RAB31, CD48, TYROBP, and LY96 identified in both the KEGG and Reactome analysis. The gene discussed is POLD2; the disease is colorectal carcinoma.