To clarify this, we employed a mouse model of pancreatic cancer development, KPC mice (Pdx1‐Cre; LSL‐KRASG12D; LSL‐p53R172H), which were bred with TFF1KO mice to generate KPC/TFF1KO mice, and the tumor characteristics including EMT were compared between these mouse models. This evidence concerns the gene PDX1 and familial pancreatic carcinoma.