GSEA analysis showed most of the pathways, including IL‐17 signaling (including IL17A, STAT3, CXCL2, and CXCL5) and cytokine‐cytokine receptor interaction signaling (including TGFBR3, IL17F, and IL10), were upregulated in ccRCC CD8+ T cell sub‐populations compared to normal human kidney tissues (Fig. 3D). Here, TGFBR3 is linked to nonpapillary renal cell carcinoma.