Previous studies have demonstrated that ATG attenuates inflammation in colitis by upregulating SIRT1 and suppressing NLRP3 and downstream IL‐1β expression,35 alleviates acute lung injury (ALI) induced by lipopolysaccharide (LPS) by activating AMPK and inhibiting the NF‐κB signaling pathway,36 and improves memory impairment in a mouse model of Alzheimer's disease by decreasing the pathological accumulation of aggregated amyloid‐beta (Aβ) via inhibition of the AKT/mTOR axis while activating AMPK.37 The gene discussed is IL1B; the disease is early-onset autosomal dominant Alzheimer disease.