JAK2/p-STAT3 protein expression was increased in NSCLC cells transfected with OE-ALKBH5, but not OE-H204A or OE-NC (Fig. 3C), implying that ALKBH5 regulates JAK2/p-STAT3 expression in a methyltransferase-dependent manner. Here, ALKBH5 is linked to non-small cell lung carcinoma.