Further, the rate of prescribed pharmacological treatment for alcohol problems (Disulfiram, Naltrexone, Acamprosate, and Nalmefene) will be measured along with the use of the biomarkers Alanine Transaminase and Gamma-Glutamyl Transferase.<h4>Methods</h4>Stepped wedge cluster randomized controlled trial in sixteen general practices in the Region of Southern Denmark. This evidence concerns the gene GPT and alcohol dependence.