Major tumor microenvironment (TME) components including stromal cells, immune cells, cancer-associated fibroblasts (CAFs), and noncellular components of the extracellular matrix (ECM) such as collagen, hyaluronan, and fibronectin, significantly contribute to fibrosis, promoting tumor progression, metastasis, and resistance to therapy [6–8]. Here, FN1 is linked to neoplasm.