When normal conditions exist, TGF-β promotes homeostasis, maintaining epithelial integrity, and anti-tumor effects such as inhibition of cell proliferation, inhibition of inflammation, and induction of apoptosis, however in a disease state it stimulates the activation of fibroblasts and subsequently triggers inflammation, angiogenesis, fibrosis, and basement membrane invasion [14]. Here, TGFB1 is linked to neoplasm.