KRAS and cancer: It is encouraging that a none-covalent pan-KRAS inhibitor, BI-2865, firstly published in Nature by Memorial Sloan-Kettering Cancer Center, exhibited excellent activity in blocking the great mass of KRAS variants including G12D/C/A/F/V/S, G13D/C, V14I, Q22K, L19F, D33E, K117N, Q61H, and A146T/V, and dramatically restricted KRAS-driven tumor growth without harming animal weight [28], suggesting BI-2865 with a good development and application prospect.