As the most well-characterized member of the mammalian C-terminal Eps15 homology (EH) domain-containing protein (EHD) family, EHD1 has been implicated in the resistance to EGFR-TKI in NSCLC through activation of PTEN/PI3K/AKT signaling [120]. Here, EHD1 is linked to non-small cell lung carcinoma.