Similarly, Heilman et al. [28] compared 30 children with T1DM (4.7–18.6 years) and healthy control subjects (4.7–18.6 years old) in terms of bone mineral density, glycemic control, OS (intercellular adhesion molecule-1 [ICAM-1]) and inflammation (high sensitivity C-reactive protein [hs-CRP], and urinary 8-iso prostaglandin F2a [F2-IsoPs]). This evidence concerns the gene CRP and type 1 diabetes mellitus.