Identified pathogenic variants (PVs) confer variable levels of PC risk, and variants are predominantly found in genes predisposing to breast cancer (ATM, BRCA1, BRCA2, PALB2) and colorectal cancer (MLH1, MSH2, MSH6, PMS2 and EPCAM) [10, 11]. The gene discussed is BRCA1; the disease is breast carcinoma.