Administration of αPK (400 μg/kg at day 3 + 4, 200 μg/kg at day 5–7) reduced activated PK and its downstream protein bradykinin in the blood at day 5 and day 7 after cerebral ischemia compared to IgG-treated control mice (Fig. 2A + B). The gene discussed is KNG1; the disease is Cerebral ischemia.