At this time, the phosphorylation of mixed lineage kinase domain-like protein (MLKL) occurs, adopting an active conformation that forms pores or directly damages cell membrane integrity, ultimately leading to cell death, releasing mtDNA to activate cGAS-STING, which has been confirmed in the disease process of aortic dissection [41], and whether MLKL phosphorylation mediated mtDNA release also exists in Kawasaki disease requires further study. The gene discussed is CGAS; the disease is Kawasaki disease.