Female 3xTg-AD samples showed significantly higher levels of Aβ42 in the frontal cortex compared to males (p = 0.037, Wilcoxon rank-sum), and higher total and phosphorylated tau at a pathologically relevant residue (T181) [89] in the hippocampus compared to male samples (p < 0.0001, Wilcoxon rank-sum; Fig. 2C, Table S3). This evidence concerns the gene MAPT and Alzheimer disease.