MAPT and Alzheimer disease: In total, our data define an acute neuroimmune cascade of mild traumatic brain injury in 3xTg-AD mice, consisting of (i) an immediate decrease in neuronal homeostatic gene expression and an elevation of AD-associated genes after a single injury, (ii) elevation of a subset of cortical cytokines that correlated with phosphorylated tau and co-labeled with neurons in injured mice, and (iii) increased expression of non-neuronal genes suggesting glial reactivity within days of repeated injury.