Finally, we generated a Venn diagram to identify overlapping genes from the three machine learning methods (Fig. 5D), resulting in nine significant genes, including FAM174B, PMP22, ATF4, DLD, ELOB, CTDP1, SV2B, USP10, and PHACTR1, all closely associated with the prognosis of IPF patients. The gene discussed is PHACTR1; the disease is idiopathic pulmonary fibrosis.