Like most models of FXS, the D.melanogaster FXS model was created by deleting the human FMR1 homolog, Fmr1 [31] and many cellular, molecular, and physiological deficits found in Fmr1-KO Drosophila overlap with those found in other animal models and the symptoms of FXS patients [26, 27, 37] (Table S1). This evidence concerns the gene FMR1 and fragile X syndrome.