FMR1 and fragile X syndrome: Transcriptomic analysis using RNA sequencing and FMRP target identification using crosslinking immunoprecipitation followed by RNA sequencing (CLIP-seq) demonstrate that FXS and FMR1-KO NPCs have upregulation of genes involved in proliferation, but downregulation of genes related to neuronal differentiation, neuronal morphology, and synaptogenesis [19].