While there are reports of these DElncRNAs in fibrotic diseases, for instance, Yang et al. demonstrated that KCNQ1OT1 regulates lung fibrosis by modulating Rtn3 expression in a lipopolysaccharide-induced acute lung injury mouse model, the specific pathways and cellular functions involved in this process require further investigation (Yang et al. 2022).Similarly, Wang et al. reported that XIST influences lung fibrosis development by modulating β-catenin expression through miR-139(Wang et al. 2017b). Here, RTN3 is linked to acute lung injury.