These lesions were not detected by omitting the primary AT8 antibody (Supplementary Fig. 2) and were classified as neuritic plaques in APPswe/PS1dE9 mice [16, 32] as well as in other mouse models of AD as APP-KI and 5X-FAD [33], APPswe/PS1L166P [34] or Tg2576 [35]. Here, APP is linked to Alzheimer disease.