In hepatocellular carcinoma (HCC), both the H19 lncRNA and m5C methylation are increased, which is significantly related to m5C-induced H19 lncRNA expression and is uniquely connected to the Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1). This evidence concerns the gene G3BP1 and hepatocellular carcinoma.