MiR23a and MiR27a suppress Jak1/Stat6 and Irf4/Ppar-γ of the Jak1/Stat6 pathway, respectively, again supporting how the Mir-23-27-24 clusters adopt a double-negative feedback loop in macrophage polarization networks, further providing evidence of their key regulatory activity in cancer progression. The gene discussed is STAT6; the disease is cancer.