ELOC and cancer: In addition, the Alu element of the sprouty RTK signaling antagonist 4 intronic transcript 1 (SPRY4-IT1) lncRNA, which is associated with aggressive behavior and poor prognosis in human cancers, can bind to the 3′ UTR of the transcription elongation factor B subunit 1 (TCEB1) mRNA, which inhibits TCEB1 expression to promote cell metastasis78.