In contrast, distributions of IAR perfect matches by donor group (HC, T1D, and newT1D), cell type (CD4 + , CD8 + ), or HLA class II alleles did not differ significantly from the distributions in total PIT TCRs (Supplementary Fig. 1C and D) (all p-values > 0.05, Fisher’s exact test). This evidence concerns the gene CD4 and type 1 diabetes mellitus.