This issue is consequent to the combined interpretation of both criteria sets that will require future resolution.7 The frequency of MOG-Ab in adults with unilateral optic neuritis ranges from 1.7% in the US optic neuritis treatment trial12 to 5% in a more recent US cohort13 and 20.2% in China.14 In binocular simultaneous optic neuritis, MOG-Ab seropositivity increases to 26.3%–66.7%.14 Only 5 patients (4 of whom were adults) fulfilled the MOGAD criteria (i.e., they were MOG-Ab positive and had at least 1 supporting feature) but had a diagnosis of MS (e.g., false positive). Here, MOG is linked to optic neuritis.